It's true they had some things in common, but not as many as maybe they would have thought before. Niles and Frasier could look startlingly similar — face-swap similar — and even an untrained eye could pick that out if they were standing side-by-side. And, true to Winchesters' guess, they weren't the best lab partners, so to speak. Where Frasier struggled, Niles usually succeeded, and vice versa, up to a point. Where it didn't really seem to matter — from the cultural aspect — they certainly seemed to resemble one another.

"That must be a practice in patience and thrilling all at once. Don't you worry you might find your personal judgement compromised where your close kin is involved?" Niles considered his question and decided to rephrase: "Meaning, how do you maintain your objectivity in a situation where your brother is at risk and maintaining his safety is directly contrary to your mission?"